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  • [Archive]
  • Journal of Pharmacopuncture
  • pISSN : 2093-6966
  • eISSN : 2234-6856
  • DB Construction : 59 Issues, 667 Articles
Year
Issues
Articles
1 Title
Keywords Acupoint; Intradermal injection; Alcian blue; Tracing; Superficial Bonghan duct and corpuscle; Immunohistochemistry; Drug delivery
Author(s) Sung, Baeck-Kyoung; Kim, Min-Su; Ogay, Vyacheslav; Kang, Dae-In; Soh, Kwang-Sup
  Abstract Objective In this article, we report on the intradermal Alcian blue staining method for tracing the meridians of acupuncture. Methods 1% Alcian blue solution was injected into acupoints by using a 0.5mL insulin syringe with a 31-gauge needle, then the skin was incised and was observed under a stereoscopic microscope. The specimens were examined by using immunohistochemical methods and were observed under a confocal laser scanning microscope. Results A threadlike structure, which was visualized with Alcian blue, existed in dermis layer and proceeded to hypodermis. In this structure, characteristic alignments of rod- shaped nuclei and sized DNA granules were observed. Furthermore, abundant blood capillary plexuses, peripheral nerve endings, and a corpuscle-like structure(about in diameter) were visualized in the skin tissues of acupoints. Conclusion It was concluded that the specific threadlike and corpuscle-like structures corresponded to superficial Bonghan duct and corpuscle, respectively.
2 Title
Keywords Intravenous Cultivated Wild Ginseng Pharmacopuncture, Non-Small Cell Lung Cancer
Author(s) Bang, Sun-Hwi; Kwon, Ki-Rok; Yoo, Hwa-Seung
  Abstract Objectives To investigate the therapeutic effects of intravenous cultivated wild ginseng(Panax ginseng C.A. Meyer) pharmacopuncture(CWGP) in treating patients with non-small cell lung cancer(NSCLC). Design Prospective case series. Setting This study was conducted at the East-West Cancer Center of Dunsan Oriental Hospital, Daejeon University. Patients Two non-small cell lung cancer patients. Intervention Two non-small cell lung cancer patients were injected CWGP(20mL/day) mixed with 0.9% normal saline(100mL) intravenously. Each patient received a total of 16 and 9 cycles, respectively. One cycle is composed of 14 days. Outcome Measures The effect of intravenous CWGP was measured by scanning with computed tomography(CT) after every 2 cycle and Positron emission tomography- computed tomography(PET/CT) after every 6 cycles. Response and progression was evaluated using the Response Evaluation Criteria in Solid Tumors(RECIST) Committee classification of complete response(CR), partial response(PR), progressive disease(PD) and stable disease(SD). Results They were treated with intravenous CWGP for 8 and 5 months respectively. time later, each tumor remains stable disease(SD). Conclusion These cases may give us a possibility that intravenous CWGP offers potential benefits for non-small cell lung cancer patients.
3 Title
Keywords Bee Venom Pharmacupuncture(BVP); warm needling(WN); osteoarthritis; KWOMAC; SF-36; Patient Global Assessment; Randomized Controlled Trial
Author(s) Yang, Ka-Ram; Song, Ho-Sueb
  Abstract Objective This study was performed to investigate whether Bee Venom Pharmacopuncture(BVP) could be a more effective modality than Warm Needling(WN) in relieving pain and symptoms of knee osteoarthritis(OA). Design Prospective, randomized and controlled clinical trial. Setting Single center trial in Korea Patients 49 volunteers with knee OA participated in the study. All the participants were screened through an inclusion and exclusion criteria. 33 participants were completed the clinical trial. Intervention The subjects were randomly assigned to one of two groups. One group received BVP(n=18), while the other group received WN(n=15). Sixteen sessions of BVP or WN were given at the pain region of the problematic knee for 8 weeks. Primary outcome measure is the Korean translation of Western Ontario and McMaster Universities Osteoarthritis Index scores(Korean WOMAC, KWOMAC). Secondary outcome measure is the physical health scores based on the 36-Item Short-Form Health Survey(SF-36) and Patient Global Assessment(PGA). KWOMAC and SF-36 were measured third (baseline, 4 and 8 weeks). PGA was measured twice(4 and 8 weeks). Results BVP group showed significant decrease compared to WN group in pain, function and total scores of KWOMAC according to the Mann-Whitney U-test. In the PGA, BVP group, compared to WN group, showed a significant increase. Conclusions BVP was more effective in relieving pain of knee OA than WN. These findings suggest that BVP is a promising alternative for treating knee OA.
4 Title
Keywords Sweet Bee Venom; clinical study; obesity; abdominal fat accumulation
Author(s) Lim, Chung-San; Park, Won-Pil; Jang, Seong-Bong; Choi, Young-Chon; Kim, Kwan-Soo; Kwon, Ki-Rok; Lee, Hee-Choon
  Abstract Objective The purpose of this study was to investigate the effects of Sweet Bee Venom to the abdominal fat accumulation clinically. Methods The 20 healthy women volunteers who showed the notice of this study by the home page of Sangji University were treated with Sweet Bee Venom(SBV) during twenty times. To investigate the effects of Sweet Bee Venom of the abdominal fat accumulation, abdominal CT, LFT, Thermography, BMI, Inbody 3.0 etc. were performed during clinical trials. And statistical analysis was carried out the data of 10 volunteers who performed all the schedule of this study. Results Following results were obtained from the clinical studies Sweet Bee Venom showed the effect of decreased the body weight, thickness of abdominal skin and fat layer, BMI, and increased abdominal heat, but they are not showed statistical significant. Conclusions These results suggest that treatment Sweet Bee Venom on the abdomen was effective to decrease fat tissue but for the treatment of obesity was performed with right diet program and exercise.
5 Title
Keywords Hyperlipidemia; HK-1001; Pharmacopuncture; GB34(Yangleungchean)
Author(s) Kim, Ji-Nam; Hong, Kwon-Eui
  Abstract Objective&Methods The purpose of this study is to observe the effects of HK-1001 Pharmacopuncture at GB34(Yangleungchean) on hyperlipidemia in rats. The author performed several experimental items to analyze the levels of various components and enzymes in serum, urine and liver, as well as the histological changes of liver and aorta. Results 1. HK-1001 Pharmacopuncture infusion solution increased the cell viability rate, DPPH radical scavenging activity and HMG-CoA reductase inhibition rate in rat liver cells. 2. The levels of total cholesterol, free cholesterol, LDL-cholesterol, phospholipid in serum and AI(atherogenic index) were decreased, and the ratio of HDL to TCL(HDL/TCL) and the level of TG in serum were increased as compared with those of the control group. 3. In the HK-1001 group, serum GOT was significantly lower than those of the HG group and the saline group, and serum ALP was significantly higher than that of the HG group. 4. Hepatic GSH and catalase activities were significantly increased as compared with those of the saline group. Conclusion From the above results, it is suggested that HK-1001 Pharmacopuncture at GB34 has a therapeutic effect on hyperlipidemia.
6 Title
Keywords Bee Venom; Sweet Bee Venom; New Sweet Bee Venom; double blind test; allergy response; pain sense
Author(s) Lim, Chung-San; Park, Won-Pil; Jang, Seong-Bong; Choi, Young-Chon; Park, Do-Il; Kwon, Ki-Rok; Lee, Hee-Choon
  Abstract Objective Sweet bee venom is made by removing allergen from the bee venom through gel filtration chromatography and propionic acid/urea polyacrylamide gel electrophoresis. The aim of this study was to verify allergy inhibitory action in Sweet Bee Venom(SBV) and New Sweet Bee Venom(NSBV) removed enzymes and compounds of low molecular weight. Methods 84 healthy adult men and women were selected through a survey whom had never received the bee venom therapy in the past. The concentration of Normal Saline, SBV and NSBV pharmacopuncture was equally at 0.1mg/mL and the experiment was conducted as the double blind test. Results Participants of the study was comprised of 63 men and 21 women with the average age of 28.3 years. According to results of pain sense, SBV group showed significant higher score compared with NS group and NSBV group using VAS in treating time. And SBV and NSBV group showed significant higher score compared with NS group after 30 minutes. Other allergic responses were insignificant between the groups. Conclusions As a result of removed allergen and compounds of low molecular weight, NSBV significantly inhibits pain sense in treating time compared with SBV. This indicates wider and easier application of NSBV for the useful application in clinical treatment. Further comparative studies should be conducted to yield more objective verification.
7 Title
Keywords Crataegi Fructus; pharmacopuncture; preadipocyte; adipocytes; lipolysis
Author(s) Won, Seung-Hwan; Kwon, Ki-Rok; Rhim, Tae-Jin; Kim, Dong-Heui
  Abstract Objectives The purpose of this study is to investigate the effects of Crataegi Fructus Pharmacopuncture(CFP) on the adipogenesis in 3T3-L1 cells, lipolysis in rat epididymal adipocytes and histological changes in porcine adipose tissue. Methods Inhibiton of preadipocyte differentiation and/or stimulation of lipolysis play important roles in reducing obesity. 3T3-L1 preadipocytes were differentiated with adipogenic reagents by incubating for 3days in the absence or presence of CFP ranging from 0.01 to 1mg/mL. The effect of CFP on adipogenesis was examined by measuring GPDH activity and by Oil Red O staining. Mature adipocytes from rat epididymal fat pad was incubated with CFP ranging from 0.01 to 1mg/mL for 3 hrs. The effect of CFP on lipolysis was examined by measuring free glycerol released. Fat tissue from pig skin was injected with CFP ranging from 0.1 to 10mg/mL to examine the effect of CFP on histological changes under light microscopy. Results The following results were obtained from present study on adipogenesis of preadipocytes, lipolysis of adipocytes and histological changes in fat tissue. 1. Crataegi Fructus Pharmacopuncture inhibited adipogenic differentiation at the concentration of 1.0mg/mL. 2. Crataegi Fructus Pharmacopuncture decreased the activity of glycerol-3-phosphate dehydrogenase(GPDH) at the concentration of 0.1mg/mL. 3. Crataegi Fructus Pharmacopuncture ok. lipolysis at the concentration of 0.1mg/ml. 4. Crataegi Fructus Pharmacopuncture ranging 0.1 to 10mg/mL failed to exert lysis of cell membrane in porcine fat tissue. Conclusions These results suggest that Crataegi Fructus Pharmacopuncture at relatively high concentration inhibited adipogenesis and increased lipolysis of adipocytes. However, Crataegi Fructus Pharmacopuncture didn't exert any effect on lysis of cell membrane in fat tissue.
8 Title
Keywords Soyeomp pharmacopuncture solution; eye irritation test; eye drop
Author(s) Seo, Hyeong-Sik
  Abstract Objectives This study was done to investigate the safety of Soyeom pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration(2005. 10. 21, KFDA 2005-60). After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, the auther observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results 1. After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't physical problem at 9 rabbits. 2. After Soyeom pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions I suggested that Soyeom pharmacopuncture solution didn't induced eye irritation in rabbits.
9 Title
Keywords Bovis Calculus pharmacopuncture solution; eye irritation test; eye drop
Author(s) Seo, Hyeong-Sik
  Abstract bjective This study was done to investigate the safety of Bovis Calculus pharmacopuncture solution manufactured with freezing dryness method to use eye drop. Methods The eye irritation test of this material was performed according to the Regulation of Korea Food & Drug Administration (2005. 10. 21, KFDA 2005-60). After Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, the auther observed eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Results 1. After Bovis Calculus pharmacopuncture solution was medicated in the left eye of the rabbits, there wasn't physical problem at 9 rabbits. 2. After Bovis Calculus pharmacopuncture solutionwas medicated in the left eye of the rabbits, there wasn't eye irritation of the cornea, iris, conjunctiva at 1, 2, 3, 4 & 7day. Conclusions I suggested that Bovis Calculus pharmacopuncture solution didn't induced eye irritation in rabbits.
10 Title
Keywords cultivated ginseng; red ginseng; cultivated wild ginseng; red wild ginseng; HPLC
Author(s) Lee, Jang-Ho; Kwon, Ki-Rok; Cha, Bae-Chun
  Abstract Objectives The aim of this experiment is to provide an differentiation of ginseng, red ginseng, cultivated wild ginseng(CWG), and red wild ginseng(RWG) through component analysis using HPLC(High Performance Liquid Chromatography, hereafter HPLC). Methods Comparative analyses of ginsenoside , ginsenoside , and ginsenosides and of various ginsengs were conducted using HPLC. Results 1. CWG was relatively heat-resistant and showed slow change in color during the process of steaming and drying, compared to cultivated ginseng. 2. Ginsenoside was not detected in cultivated ginseng and CWG, whereas it was high in red ginseng and RWG. Ginsenoside was more generated in red ginseng than in RWG. 3. Ginsenoside appreared during steaming and drying of cultivated ginseng, whereas it was more increased during steaming and drying of CWG. 4. Ginsenoside content was more increased during steaming and drying of cultivated ginseng, whereas it was more decreased during steaming and drying of CWG. 5. Ginsenoside content was increased about 500% during steaming and drying of cultivated ginseng, whereas it was increased about 30% during steaming and drying of CWG, indicating that ginsenoside was more generated in red ginseng than in RWG. 6. Ginsenoside content was higher, whereas ginsenoside content was lower in 11th RWG than in 9th RWG, indicating that ginsenoside content was increased and content was decreased as steaming and drying continued to proceed. Ginsenoside and contents began to be increased, followed by decreased after 9th steaming and drying process. Conclusions Above experiment data can be an important indicator for the dentification of ginseng, red ginseng, CWG, and RWG. And the following studies will be need for making good product using CWG.
11 Title
Keywords
Author(s) Lee, Hee-Yoon; Youn, Hyoun-Min; Kim, Won-Il
  Abstract Objectives This study is for comparing the results in two groups of using Oriental medical treatment only with using Oriental-Western medical treatment together to shoulder pain patients. Methods 49 shoulder pain patients who participated in the clinical study both at the Bukpyeoung Haemalkeun Oriental Medical Clinic and at the Bukpyeoung Medical Clinic in Donghae city were classified 2 groups. Group A was treated with Oriental medical therapy only and group B was treated with Oriental-Western medical treatment together. They have been treated 3 times a week for 4 weeks. Results After 1, 2 and 4 weeks of each treatment, the scores of the two groups in 'Subjective symptoms of shoulder pain', 'Indisposition index of every day life', 'Shoulder pain and disability index', 'Visual analog scale' became signific antly lower than those before treatment. Conclusion Treatment of group B was better than treatment of group A but, there was no significant difference in therapeutic action between two groups.
12 Title
Keywords Sweet Bee venom; Molluscum Contagiosum; Pharmacopuncture
Author(s) Park, Sa-Han; Kim, Tae-Sik; Hur, Young-Jin; Kwon, Ki-Rok
  Abstract Objectives This study obserbed the efficiency of Sweet Bee Venom pharmacopuncture on the treatment of 70 Molluscum Contagiosum cases. Methods 70 patients admitted for Molluscum at Love Blossoming Oriental medicine clinic from February 2007 to October 2007 were administered with Sweet Bee Venom Pharmacopuncture and measured an analyzed changes in symptoms. Results 1. Regardless of age or duration of Molluscum Contagiosum, all 70 patients showed improvement. 2. Recurrence of Molluscum Contagiosum was not noticeable when treated with Sweet Bee Venom Pharmacopuncture, and the duration of treatment was significantly shorter than treation with conventional allopathic ointment. Conclusion Based on above findings, we can deduce Sweet Bee Venom Pharmacopuncture has superior anti-viral effects on th pox virus of Molluscum Contagiosum.
13 Title
Keywords Scolopendrid Pharmacopuncture(Herbal-Acupuncture); Cauda equina; bladder incontinence; bilateral sciatica; saddle anesthesia; SF-36
Author(s) Lee, Hwi-Yong; Cho, Yi-Hyun; You, Jeong-Seok; Yook, Tae-Han; Hong, Kwon-Eui
  Abstract Objective This study was investigated on the Scolopendrid Pharmacopuncture of Caude equina syndrome which has been described as a complex of low back pain, bilateral sciatica, saddle anesthesia and motor weakness in the lower extremity that progress to paraplegia with baldder and bowel incontinence. Methods & Results Clinical observation was done on Cauda equina syndrome in the Department of Acupuncture & Moxibustion, Woosuk jeonju Oriental Medical Hospital frome May 30 to July 13. The patient was treated with Scolopendrid Pharmacopuncture at Shinsu(B23), Gihaesu(B24), Taejangsu(B25), Gwanweonsu(b26), Dangryo(b31), Charyo(b32), Jang-gang(gv1) and Hoe-eum(cv1) with Oriental Medicine treatment. We evaluated SF-36, the bladder incontinence, bowel incontinence, sensibility by sting skin, before and after treatmeat. Conclusion 1. At the early time, gait disturbance was treated well, but discomfort of bladder incontinence, bilateral sciatica, saddle anesthesia and motor weakness was remained. 2. The symptoms of Cauada equina syndrome, especially bladder incontinence and bilateral sciatica, was recurred in short duration by scolopendrid Pharmacopuncture and oriental medicine treatment.
14 Title
Keywords Benign Prostatic Hyperplasia; Bee Venom Pharmacopunture Therapy
Author(s) Gang, Hyeon-Min; Kim, Gwan-Soo; Kim, Doo-Yong; Ryu, Young-Jin; Park, Hee-Soo; Kwon, Ki-Rok
  Abstract Objective The purpose of this study was to report the efficiency of Bee Venom Pharmacopunture Therapy by managering of Benign Prostatic Hyperplasia patients. Method Two patients were treated with Bee Venom Pharmacopunture and another Korean Medicine therapy for six weeks and compared with I-PSS(International Prostate Symptom Score) before and after. Results After treated with Bee Venom Pharmacopunture Therapy, 'I-PSS' values decreased significantly all the patients. Conclusions Bee Venom Pharmacopunture Therapy was shown fairly effective to Benign Prostatic Hyperplasia.
15 Title
Keywords sequelae of spinal SAH; Dong's acupuncture therapy; pharmacopuncture therapy; Mae-sun therap
Author(s) Lee, Kyoung-Hee; Lo, Ju-Hwan; Youn, Hyoun-Min; Jang, Kyung-Jeon; Ahn, Chang-Beohm; Kim, Cheol-Hong
  Abstract Objective Spinal SAH is an unusual disease that occasionally occurs spinal cord injury. This report intended to estimate the effect that taken by using oriental treatment on the patient with the sequelae of spinal SAH. Methods We have observed this case of patient treated by Dong's acupuncture therapy, pharmacopuncture therapy, Mae-sun therapy and herbal medication, etc. Results The patient showed improvements in pain, power and sensory function. Conclusion Oriental treatments such as Dong's acupuncture therapy, pharmacopuncture therapy, Mae-sun therapy and herbal medication can be effective for the sequelae of spinal SAH.
16 Title
Keywords Transverse myelitis; Arthralgia syndrome; Oriental medical treatment
Author(s) Kim, Jeong-Eun; Kim, Su-Min; Yoon, Hyun-Min; Ahn, Chang-Beohm; Jang, Kyung-Jun; Kim, Cheol-Hong; Kim, Jae-Hong; Kim, Won-Il
  Abstract Objectives This report intended to estimate effect taken by using Oriental medical method on the patient with Tranverse Myelitis. Methods From 28th April, 2006 to 19th June, 2006. The patient dignosed as a Transverse Myelitis receive acupuncture, moxibustion, cupping and physical therapy and herbal medication by estimating arthralgia syndrome(痺證). Results The patient's incipient symptoms-both lower limb paresthesia and weakness, voluntary urination and defecation-all were improved. Conclusions This study demonstrates that oriental medical treatment has respectable effect in improving as though we didn't exclude effect of western medical therapy on the patient with transverse myelitis. More research of transverse myelitis is needed.